Opportunity Information: Apply for RFA CA 21 022
The National Cancer Institute (NCI), through the National Institutes of Health, offered this cooperative agreement (U24; clinical trial not allowed) to fund a single Coordinating Center for the Metabolic Dysregulation and Cancer Risk Program. The program is built around the idea that metabolic dysregulation is a central biological process connecting obesity to increased cancer risk. Rather than funding one stand-alone research project, this opportunity supports an infrastructure and leadership hub whose job is to keep multiple separately funded research teams working as one integrated program, with shared approaches, aligned measurements, and coordinated outputs that collectively improve understanding of how obesity-related metabolic changes contribute to cancer development.
The main purpose of the Coordinating Center is to provide program-wide coordination, administration, and collaboration support across multiple individual research project grants funded under a companion announcement (RFA-CA-21-021; U01; clinical trial optional). Together, the U24 Coordinating Center award and the U01 research awards make up the full Metabolic Dysregulation and Cancer Risk Program. In practice, that means the Coordinating Center is expected to be an active partner in shaping how the overall program operates day-to-day and how it produces consistent, comparable science across different projects and institutions. Because the mechanism is a cooperative agreement, NCI involvement is typically more substantial than in a standard grant, with NIH and awardees working in partnership on oversight, coordination, and program direction.
The Coordinating Center responsibilities are broad and operationally heavy. It is expected to provide administrative support for the entire program, including organizing and supporting meetings, facilitating communication among investigators, and keeping collaborative activities on track. A major scientific coordination role is to help establish standard operating procedures (SOPs) and best practices so that projects can use common measures, targets, and methods where appropriate. This includes identifying and managing core common data elements that can be collected across studies to enable pooled analyses and cross-project comparisons. When appropriate for the program, the Coordinating Center may also help coordinate the collection of biological samples, with an emphasis on ensuring consistent handling, documentation, and alignment with shared protocols so that biospecimen-related findings can be interpreted across studies.
Another key function is information and resource management. The Coordinating Center is tasked with creating and maintaining a program website to serve as a central home for program information, resources, and coordination materials. It also supports data stewardship by helping facilitate deposition of datasets into NIH-designated repositories when appropriate, which typically involves establishing expectations for formatting, metadata, timing, access controls, and compliance with NIH data sharing policies. Additionally, the description indicates the Coordinating Center may coordinate reviews of applications and the distribution of research funds, reflecting a role in internal program processes that support how collaborative work is selected, supported, and managed across the network.
Eligibility for this opportunity is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The announcement also highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Foreign eligibility is limited in a specific way. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply as applicants. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed, meaning a U.S. applicant organization could include certain justified foreign collaborations or activities under NIH rules even though a foreign institution cannot be the primary applicant.
Administratively, the opportunity is identified as RFA-CA-21-022, categorized as discretionary funding, and uses a cooperative agreement funding instrument. The activity category is listed under education and health, with CFDA number 93.393. The original closing date was October 6, 2021, and the posting indicates an award ceiling of $550,000. Overall, this FOA is best understood as funding the backbone of a coordinated research network: the systems, standards, communications, data practices, and shared infrastructure needed to turn multiple independent obesity-and-cancer research projects into a coherent, transdisciplinary program focused on metabolic dysregulation and cancer risk.Apply for RFA CA 21 022
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Coordinating Center for the Metabolic Dysregulation and Cancer Risk Program: A Transdisciplinary Approach to Obesity-Associated Cancer Research (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393.
- This funding opportunity was created on 2021-07-06.
- Applicants must submit their applications by 2021-10-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $550,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the main goal of this funding opportunity (RFA-CA-21-022)?
This opportunity funds a single Coordinating Center for the Metabolic Dysregulation and Cancer Risk Program. The Coordinating Center acts as the program-wide infrastructure and leadership hub that keeps multiple separately funded research teams operating as one integrated program, with coordinated operations, shared approaches, aligned measurements, and consistent outputs focused on how obesity-related metabolic dysregulation contributes to cancer risk.
What kind of award mechanism is this?
This is a cooperative agreement using the U24 activity code (clinical trial not allowed). As a cooperative agreement, it is designed for substantial involvement by NCI/NIH staff in partnership with the awardee on oversight, coordination, and program direction, rather than the more independent structure typical of many standard grants.
How does the U24 Coordinating Center fit with the rest of the program?
The U24 Coordinating Center award works together with multiple individual research project grants funded under a companion announcement (RFA-CA-21-021; U01; clinical trial optional). The U24 and the U01 awards collectively make up the full Metabolic Dysregulation and Cancer Risk Program, with the Coordinating Center enabling cross-project consistency and collaboration.
Is this opportunity funding a stand-alone research project?
No. The focus is not a single independent research project. It supports the backbone functions needed to coordinate and integrate multiple separately funded research projects into a coherent, collaborative program.
How many Coordinating Centers will be funded?
The announcement indicates funding for a single Coordinating Center.
Are clinical trials allowed under this U24 Coordinating Center award?
No. The U24 Coordinating Center mechanism is described as "clinical trial not allowed."
What are the primary responsibilities of the Coordinating Center?
The Coordinating Center is expected to provide broad, operationally intensive program-wide support, including administration, coordination, and facilitation of collaboration among the research teams. This includes organizing meetings, supporting communications, and helping ensure collaborative activities remain aligned and on track across projects and institutions.
What role does the Coordinating Center play in standardization across projects?
A key scientific coordination responsibility is to help establish standard operating procedures (SOPs) and best practices so projects can use common measures, targets, and methods where appropriate. This is intended to make results more comparable and to support cross-project analyses.
What are "core common data elements" in this program context?
The Coordinating Center is expected to identify and manage core common data elements that can be collected across studies. These shared elements are meant to enable pooled analyses and cross-project comparisons by improving consistency in what data are collected and how they are described.
Does the Coordinating Center manage biospecimen collection?
When appropriate for the program, the Coordinating Center may help coordinate the collection of biological samples, emphasizing consistent handling and documentation and alignment with shared protocols. The goal is to support interpretation of biospecimen-related findings across different studies.
Is creating a program website part of the required work?
Yes. The Coordinating Center is tasked with creating and maintaining a program website as a central home for program information, resources, and coordination materials.
What data sharing or repository expectations are mentioned?
The Coordinating Center supports data stewardship by helping facilitate deposition of datasets into NIH-designated repositories when appropriate. This typically includes establishing expectations for formatting, metadata, timing, access controls, and compliance with NIH data sharing policies.
Does the Coordinating Center have responsibilities related to internal reviews or distributing funds?
Yes. The description indicates the Coordinating Center may coordinate reviews of applications and the distribution of research funds, reflecting a role in internal program processes that support how collaborative work is selected, supported, and managed across the network.
Which organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and governmental entities, including state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses.
Are U.S. territories or possessions eligible?
Yes. The eligibility description includes U.S. territories or possessions.
Are faith-based or community-based organizations eligible?
Yes. The announcement highlights faith-based or community-based organizations among eligible categories.
Are specific institution types (for example, HBCUs or HSIs) eligible?
Yes. The announcement highlights additional eligible categories including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Can a non-U.S. organization apply as the primary applicant?
No. Non-domestic (non-U.S.) entities are not eligible to apply as applicants, and non-domestic components of U.S. organizations are also not eligible to apply as applicants.
Are foreign collaborations allowed in any form?
Yes, in a limited way. Foreign components (as defined in the NIH Grants Policy Statement) are allowed. This means a U.S. applicant organization may include certain justified foreign collaborations or activities under NIH rules, even though a foreign institution cannot be the primary applicant.
What is the sponsoring agency and program area?
The opportunity is offered by the National Cancer Institute (NCI) through the National Institutes of Health. The activity category is listed under education and health.
What is the CFDA number for this opportunity?
The CFDA number provided is 93.393.
What is the funding instrument type?
The funding instrument is a cooperative agreement.
What is the award ceiling mentioned in the posting?
The posting indicates an award ceiling of $550,000.
What was the original closing date?
The original closing date listed was October 6, 2021.
What does "discretionary funding" mean in this listing?
The opportunity is categorized as discretionary funding in the posting. The provided description does not add further detail beyond that classification.
In practical terms, what does the Coordinating Center do day-to-day?
Based on the description, day-to-day operations include organizing and supporting meetings, facilitating communication across investigators, maintaining shared coordination resources (including a program website), supporting the development and maintenance of SOPs and best practices, managing common data elements, and helping align data and biospecimen practices so results can be compared and combined across projects.
What scientific theme ties the program together?
The program is built around the idea that metabolic dysregulation is a central biological process connecting obesity to increased cancer risk, and the coordinated program aims to improve understanding of how obesity-related metabolic changes contribute to cancer development.
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