Opportunity Information: Apply for RFA HL 26 010
This funding opportunity (RFA-HL-26-010) is an NIH Notice of Funding Opportunity to support the renewal of the MACS/WIHS Combined Cohort Study (MWCCS) for a new 7-year period running from 2026 through 2033. MWCCS is a long-running, U.S.-based epidemiological cohort focused on adults aging with and without HIV, and the renewal is meant to preserve and extend the value of an unusually well-characterized national cohort. The underlying rationale is that continued follow-up of the same individuals over time makes it possible to study how HIV and its treatments interact with aging, comorbidities, and social and environmental conditions in ways that cannot be captured well in shorter studies or purely clinical datasets.
A central feature of the renewal is the continued longitudinal follow-up of roughly 5,500 deeply phenotyped participants recruited across the United States. The cohort includes middle-aged and older people living with HIV (PLWH) as well as comparable people living without HIV (PLWOH), allowing analyses that separate HIV-specific effects from the broader effects of aging and shared risk factors. The NOFO emphasizes that MWCCS is designed to generate rich, multi-level data over time, enabling research on health outcomes, quality of life, and survival in the context of modern HIV care and the realities of aging.
The scientific approach highlighted in the announcement is "populomics," meaning the study of health determinants across multiple, interacting scales of influence. In practice, this framing encourages integrated analyses that can span molecular and cellular measures through physiological and clinical indicators, and up through lifestyle and behavioral factors, household context, neighborhood and environmental exposures, and cultural and sociopolitical conditions. The intention is to support multidisciplinary methods that can model a web of influences rather than treating determinants in isolation, which is especially relevant for understanding complex outcomes like multimorbidity, functional decline, and disparities in aging with HIV.
Rather than funding multiple separate projects, this NOFO specifically seeks applications to support a single Data Analysis and Sharing Center (DASC) for MWCCS. The DASC is expected to serve as the hub for data management, analysis support, and data sharing for the entire cohort enterprise, helping ensure that MWCCS data are curated consistently, analyzed rigorously, and made available in ways that maximize scientific use while protecting participants. Because the award mechanism is a U01 cooperative agreement, NIH will have substantial programmatic involvement, meaning the DASC will be expected to work closely with NIH and the broader MWCCS consortium on governance, priorities, timelines, and deliverables. The NOFO also states that clinical trials are not allowed under this opportunity.
The competition is explicitly limited: only institutions that were funded under the prior relevant solicitation (RFA-HL-19-007) may apply, with additional eligibility conditions referenced in the NOFO. Eligible applicant types listed include public and state-controlled institutions of higher education and private institutions of higher education. Foreign participation is prohibited in multiple forms: non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
Key administrative details included in the source information are that the sponsor is the National Institutes of Health, the funding instrument is a cooperative agreement (U01), the opportunity category is discretionary, and the original application closing date is May 2, 2025. The listed award ceiling is $2,000,000. Multiple CFDA (assistance listing) numbers are associated with the opportunity (93.121, 93.173, 93.233, 93.242, 93.273, 93.279, 93.307, 93.313, 93.361, 93.393, 93.837, 93.838, 93.839, 93.840, 93.855, 93.865, 93.866), reflecting NIH program alignment across institutes and topic areas tied to HIV, aging, comorbidities, and related public health priorities.Apply for RFA HL 26 010
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Limited Competition: Data Analysis and Sharing Center (DASC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.173, 93.233, 93.242, 93.273, 93.279, 93.307, 93.313, 93.361, 93.393, 93.837, 93.838, 93.839, 93.840, 93.855, 93.865, 93.866.
- This funding opportunity was created on 2025-01-16.
- Applicants must submit their applications by 2025-05-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education, Private institutions of higher education.
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Frequently Asked Questions (FAQs) - RFA-HL-26-010 (MWCCS DASC Renewal)
What is the funding opportunity RFA-HL-26-010 about?
RFA-HL-26-010 is an NIH Notice of Funding Opportunity that supports the renewal of the MACS/WIHS Combined Cohort Study (MWCCS) for a new 7-year period spanning 2026 through 2033. The goal is to preserve and extend the value of a long-running, U.S.-based epidemiological cohort focused on adults aging with and without HIV.
Who is the sponsor of this opportunity?
The sponsor is the National Institutes of Health (NIH).
What is the project period covered by this renewal?
The renewal period described in the opportunity runs for 7 years, from 2026 through 2033.
What is MWCCS and why is it being renewed?
MWCCS is a long-running national cohort study in the United States that follows adults aging with and without HIV over time. The renewal is intended to maintain continued follow-up of the same individuals so researchers can study how HIV and its treatments interact with aging, comorbidities, and social and environmental conditions in ways that shorter studies or purely clinical datasets may not capture well.
How many participants are included in MWCCS?
The opportunity describes continued longitudinal follow-up of roughly 5,500 deeply phenotyped participants recruited across the United States.
Who are the participants in the cohort?
The cohort includes middle-aged and older people living with HIV (PLWH) and comparable people living without HIV (PLWOH). This design supports analyses that can separate HIV-specific effects from broader effects of aging and shared risk factors.
What kinds of research questions is MWCCS designed to support?
MWCCS is designed to generate rich, multi-level data over time to enable research on health outcomes, quality of life, and survival in the context of modern HIV care and the realities of aging. The continued follow-up supports studying complex outcomes such as multimorbidity, functional decline, and disparities in aging with HIV.
What does "longitudinal follow-up" mean in the context of this opportunity?
In this context, it means repeatedly collecting information on the same participants over time. The opportunity highlights that this long-term follow-up is critical for understanding how factors related to HIV, treatment, aging, comorbidities, and social/environmental conditions change and interact across years.
What is meant by "deeply phenotyped" participants?
The opportunity uses this phrase to describe participants who have extensive, detailed characterization and measurements collected over time, contributing to the richness of the cohort data.
What is the "populomics" approach referenced in the announcement?
"Populomics" is described as studying health determinants across multiple interacting scales of influence. The NOFO emphasizes integrated analyses that can span molecular and cellular measures, physiological and clinical indicators, and broader influences such as lifestyle and behavioral factors, household context, neighborhood and environmental exposures, and cultural and sociopolitical conditions.
How does the populomics framing affect the type of work expected?
It encourages multidisciplinary methods that model a web of influences rather than treating determinants in isolation. This is positioned as especially relevant for understanding complex outcomes like multimorbidity, functional decline, and disparities among adults aging with HIV.
What exactly is being funded under this NOFO?
This NOFO seeks applications to support a single Data Analysis and Sharing Center (DASC) for MWCCS, rather than funding multiple separate projects.
What is the role of the Data Analysis and Sharing Center (DASC)?
The DASC is expected to serve as the hub for data management, analysis support, and data sharing for the MWCCS enterprise. The NOFO emphasizes consistent curation, rigorous analysis support, and making data available in ways that maximize scientific use while protecting participants.
Is NIH expected to be involved after an award is made?
Yes. The award mechanism is a U01 cooperative agreement, and the opportunity states this involves substantial NIH programmatic involvement. The DASC is expected to work closely with NIH and the broader MWCCS consortium on governance, priorities, timelines, and deliverables.
What is the funding instrument for this opportunity?
The funding instrument is a cooperative agreement (U01).
What is the opportunity category?
The opportunity category is discretionary.
Are clinical trials allowed under this opportunity?
No. The NOFO states that clinical trials are not allowed under this opportunity.
Who is eligible to apply?
The competition is explicitly limited. Only institutions that were funded under the prior relevant solicitation (RFA-HL-19-007) may apply, with additional eligibility conditions referenced in the NOFO. Eligible applicant types listed include public and state-controlled institutions of higher education and private institutions of higher education.
Can an institution that was not funded under RFA-HL-19-007 apply?
No. Based on the information provided, eligibility is restricted to institutions funded under RFA-HL-19-007 (and meeting additional eligibility conditions referenced in the NOFO).
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-U.S. entities are not eligible to apply.
Can a U.S. organization apply if it has a non-U.S. component involved?
No. The NOFO prohibits non-U.S. components of U.S. organizations from being eligible.
Are foreign components allowed in any form under NIH policy definitions?
No. The NOFO states that foreign components (as defined by NIH policy) are not allowed.
What is the application closing date listed for this opportunity?
The original application closing date is May 2, 2025.
What is the award ceiling?
The listed award ceiling is $2,000,000.
Is this NOFO funding multiple centers or a single center?
It is specifically seeking applications to support a single Data Analysis and Sharing Center (DASC) for MWCCS.
What is the geographic scope of the cohort described in the opportunity?
The cohort is described as U.S.-based, with participants recruited across the United States.
Why does the cohort include people living with HIV and people living without HIV?
This design supports analyses that can distinguish HIV-specific effects from broader aging-related effects and shared risk factors, since both groups are followed over time.
What kinds of determinants does the NOFO highlight as important for analysis?
The NOFO highlights determinants across multiple levels, including molecular and cellular measures, physiological and clinical indicators, lifestyle and behavioral factors, household context, neighborhood and environmental exposures, and cultural and sociopolitical conditions.
What are the Assistance Listing (CFDA) numbers associated with this opportunity?
The opportunity lists multiple Assistance Listing numbers: 93.121, 93.173, 93.233, 93.242, 93.273, 93.279, 93.307, 93.313, 93.361, 93.393, 93.837, 93.838, 93.839, 93.840, 93.855, 93.865, and 93.866.
Why are there multiple Assistance Listing (CFDA) numbers?
The information provided indicates the multiple numbers reflect NIH program alignment across institutes and topic areas tied to HIV, aging, comorbidities, and related public health priorities.
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