Opportunity Information: Apply for RFA HL 26 010
This funding opportunity (RFA-HL-26-010) is an NIH Notice of Funding Opportunity to support the renewal of the MACS/WIHS Combined Cohort Study (MWCCS) for a new 7-year period running from 2026 through 2033. MWCCS is a long-running, U.S.-based epidemiological cohort focused on adults aging with and without HIV, and the renewal is meant to preserve and extend the value of an unusually well-characterized national cohort. The underlying rationale is that continued follow-up of the same individuals over time makes it possible to study how HIV and its treatments interact with aging, comorbidities, and social and environmental conditions in ways that cannot be captured well in shorter studies or purely clinical datasets.
A central feature of the renewal is the continued longitudinal follow-up of roughly 5,500 deeply phenotyped participants recruited across the United States. The cohort includes middle-aged and older people living with HIV (PLWH) as well as comparable people living without HIV (PLWOH), allowing analyses that separate HIV-specific effects from the broader effects of aging and shared risk factors. The NOFO emphasizes that MWCCS is designed to generate rich, multi-level data over time, enabling research on health outcomes, quality of life, and survival in the context of modern HIV care and the realities of aging.
The scientific approach highlighted in the announcement is "populomics," meaning the study of health determinants across multiple, interacting scales of influence. In practice, this framing encourages integrated analyses that can span molecular and cellular measures through physiological and clinical indicators, and up through lifestyle and behavioral factors, household context, neighborhood and environmental exposures, and cultural and sociopolitical conditions. The intention is to support multidisciplinary methods that can model a web of influences rather than treating determinants in isolation, which is especially relevant for understanding complex outcomes like multimorbidity, functional decline, and disparities in aging with HIV.
Rather than funding multiple separate projects, this NOFO specifically seeks applications to support a single Data Analysis and Sharing Center (DASC) for MWCCS. The DASC is expected to serve as the hub for data management, analysis support, and data sharing for the entire cohort enterprise, helping ensure that MWCCS data are curated consistently, analyzed rigorously, and made available in ways that maximize scientific use while protecting participants. Because the award mechanism is a U01 cooperative agreement, NIH will have substantial programmatic involvement, meaning the DASC will be expected to work closely with NIH and the broader MWCCS consortium on governance, priorities, timelines, and deliverables. The NOFO also states that clinical trials are not allowed under this opportunity.
The competition is explicitly limited: only institutions that were funded under the prior relevant solicitation (RFA-HL-19-007) may apply, with additional eligibility conditions referenced in the NOFO. Eligible applicant types listed include public and state-controlled institutions of higher education and private institutions of higher education. Foreign participation is prohibited in multiple forms: non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
Key administrative details included in the source information are that the sponsor is the National Institutes of Health, the funding instrument is a cooperative agreement (U01), the opportunity category is discretionary, and the original application closing date is May 2, 2025. The listed award ceiling is $2,000,000. Multiple CFDA (assistance listing) numbers are associated with the opportunity (93.121, 93.173, 93.233, 93.242, 93.273, 93.279, 93.307, 93.313, 93.361, 93.393, 93.837, 93.838, 93.839, 93.840, 93.855, 93.865, 93.866), reflecting NIH program alignment across institutes and topic areas tied to HIV, aging, comorbidities, and related public health priorities.Apply for RFA HL 26 010
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Limited Competition: Data Analysis and Sharing Center (DASC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.173, 93.233, 93.242, 93.273, 93.279, 93.307, 93.313, 93.361, 93.393, 93.837, 93.838, 93.839, 93.840, 93.855, 93.865, 93.866.
- This funding opportunity was created on 2025-01-16.
- Applicants must submit their applications by 2025-05-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education, Private institutions of higher education.
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| Funding Opportunity |
|---|
| Limited Competition: Clinical Research Sites (CRS) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trial Not Allowed) Apply for RFA HL 26 009 Funding Number: RFA HL 26 009 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $2,400,000 |
| Leadership and Coordination Center (LACC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed) Apply for RFA HL 26 011 Funding Number: RFA HL 26 011 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $2,000 |
| Single Source: National Longitudinal Study of Adolescent to Adult (Add) Health Wave VII (U01 Clinical Trial Not Allowed) Apply for RFA AG 26 001 Funding Number: RFA AG 26 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional) Apply for PAR 25 383 Funding Number: PAR 25 383 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed) Apply for RFA DA 27 004 Funding Number: RFA DA 27 004 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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