Opportunity Information: Apply for RFA HL 19 020

The Molecular Atlas of Lung Development Program (LungMAP) Phase 2 Research Centers funding opportunity (RFA HL 19 020) is a National Heart, Lung, and Blood Institute (NHLBI) cooperative agreement (U01) designed to expand and deepen an open-access reference resource focused on human lung development. The central goal of LungMAP is to create a comprehensive, dynamic, three-dimensional molecular atlas of the developing lung, with integrated datasets and research reagents made broadly available to the scientific community. In Phase 2, NHLBI is specifically seeking Research Centers (RCs) that will generate high-resolution molecular profiling data and pair those data with spatial information so that investigators can map which molecules are present, where they are located in the tissue, and how they change across developmental stages and disease states. Clinical trials are not allowed under this announcement.

Phase 2 continues the programmatic emphasis on multiscale and high-resolution approaches, meaning the expectation is not simply to collect isolated datasets, but to produce molecular profiles that can be connected across different levels of biological organization (for example, tissue architecture, distinct anatomical regions, and individual cell types) and across time. A major scientific deliverable is molecular characterization of functionally and anatomically defined cell types in the developing human lung, supported by spatial context so that the resulting atlas is more than a list of genes or proteins and instead reflects the real organization of the lung as it forms and matures. The “dynamic” aspect of the atlas underscores that development is a process, and the resource is meant to capture transitions, maturation states, and evolving cellular composition rather than a single snapshot.

A key shift in Phase 2 is its exclusive focus on human lung, along with an expanded developmental window. Rather than concentrating only on late-stage development, Phase 2 extends coverage through normal lung development into early adulthood, defined here as up to 25 years of age. In addition, Phase 2 broadens the scope beyond normal development to include abnormal lung development in selected neonatal and pediatric rare lung diseases. This means the program is intended not only to define what typical human lung development looks like at molecular and spatial levels, but also to provide reference points for understanding how specific rare developmental disorders diverge from typical pathways, potentially clarifying disease mechanisms and highlighting cellular or molecular targets for future research.

The role of funded Research Centers under this opportunity is to serve as primary generators of molecular profiling data for the program. Because this is a cooperative agreement (U01), awardees should generally expect substantial scientific and programmatic involvement from the NIH compared with a standard research project grant, with coordination and alignment around shared goals, common standards, and resource-building priorities. The emphasis on an open-access reference resource also signals that data and reagents produced are expected to be shared with the broader community in a timely manner and in ways that support reuse, integration, and comparative analyses by outside investigators.

From an administrative and funding standpoint, the opportunity is offered by the Department of Health and Human Services through the National Institutes of Health (NIH), with the NHLBI as the sponsoring institute. The activity category is Health, and the CFDA number listed is 93.838. NHLBI anticipated making about four awards, with an award ceiling of $600,000. The original posting indicates a creation date of July 27, 2018 and an original closing date of October 31, 2018.

Eligibility is broad and includes many common organizational types that participate in NIH research, such as public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and multiple levels of government entities (state, county, city or township, special districts), as well as Native American tribal governments and tribal organizations, and public housing authorities/Indian housing authorities. Importantly, applicants do not need to have been funded under LungMAP Phase 1 to apply for Phase 2, which opens the competition to new teams that can contribute the needed molecular and spatial profiling capabilities and can operate effectively in a coordinated, consortium-style environment.

  • The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Molecular Atlas of Lung Development Program (LungMAP) Phase 2 Research Centers (U01- Clinical Trial Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838.
  • This funding opportunity was created on Jul 27, 2018.
  • Applicants must submit their applications by Oct 31, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $600,000.00 in funding.
  • The number of recipients for this funding is limited to 4 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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