Opportunity Information: Apply for RFA CA 17 061
This funding opportunity, titled "NCI National Clinical Trials Network (NCTN) - Network Group Integrated Translational Science Centers (UG1)" (RFA-CA-17-061), is a National Institutes of Health (NIH) cooperative agreement designed to support institutions and organizations that will either maintain or establish Integrated Translational Science Centers aligned with the NCI’s National Clinical Trials Network. The core aim is to strengthen the ability of NCTN Network Groups to embed translational science directly into the design and execution of their clinical trials, so that clinical studies do more than test treatments; they also generate biologic and mechanistic insights that can guide future research and patient care. In practice, these centers are meant to serve as a hub of leadership, specialized expertise, and operational support that helps Network Group trials consistently include well-planned translational components such as biospecimen collection, biomarker development, correlative science, and other research activities that connect patient outcomes with underlying biology.
A key feature of the program is that the Integrated Translational Science Centers are expected to provide scientific direction and coordination for translational efforts across Network Group trials, not just one-off support. This includes helping investigators identify translational questions that can realistically be answered within clinical trial settings, ensuring appropriate infrastructure and workflows are in place, and improving the overall quality and feasibility of translational endpoints. The FOA also explicitly includes support for pilot projects that collect preliminary data. These pilot activities are important because they allow Network Groups to test ideas, optimize methods, and generate early evidence that can justify and de-risk larger, more definitive translational components in later clinical trials. Because this is a cooperative agreement (UG1), awardees should expect substantial NIH/NCI programmatic involvement compared with a standard research grant, typically through shared governance, coordination requirements, and active collaboration to ensure the centers meet network-wide goals.
Eligibility is broad across U.S.-based organizations, reflecting the networked and multi-institutional nature of NCTN work. Eligible applicants include state governments; public and state-controlled institutions of higher education; private institutions of higher education; non-profit organizations (both those with 501(c)(3) status and those without 501(c)(3) status, as long as they are not institutions of higher education); and for-profit organizations other than small businesses. The FOA also highlights additional eligible applicant types that often appear as designated categories in federal funding, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and U.S. territories or possessions. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible to apply as components; however, "foreign components" as defined under the NIH Grants Policy Statement are allowed, meaning certain discrete collaborations or activities involving foreign entities may be permissible when they meet NIH’s definition and policy requirements, even though the applicant organization itself must be eligible and U.S.-based.
From an administrative standpoint, this opportunity falls under the NIH’s education and health activity categories and is associated with CFDA numbers 93.394 and 93.395. The original posting date is October 20, 2017, with an original application closing date of January 19, 2018. The listed award ceiling is $850,000, which signals the intended scale for a single award’s annual direct costs or total costs depending on the FOA’s specific budget instructions (applicants would need to confirm in the full announcement). While the excerpt does not provide a definitive number of expected awards, the structure suggests a targeted set of awards intended to align with NCTN Network Groups and their translational needs. Overall, the grant is best understood as capacity-building and integration funding: it supports organizational leadership, shared expertise, and pilot translational research so that translational science becomes a consistent, high-quality element of NCTN clinical trials rather than an add-on that varies from study to study.Apply for RFA CA 17 061
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NCI National Clinical Trials Network - Network Group Integrated Translational Science Centers (UG1)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
- This funding opportunity was created on 2017-10-20.
- Applicants must submit their applications by 2018-01-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $850,000.00 in funding.
- Eligible applicants include: State governments, Public and State controlled institutions of higher education, Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "NCI National Clinical Trials Network (NCTN) - Network Group Integrated Translational Science Centers (UG1)" and is identified as RFA-CA-17-061.
What type of NIH award is this?
This is an NIH cooperative agreement using the UG1 activity code.
What does it mean that this is a cooperative agreement (UG1)?
Because it is a cooperative agreement, awardees should expect substantial NIH/NCI programmatic involvement compared with a typical research grant. This can include shared governance, coordination requirements, and active collaboration to help ensure the centers meet network-wide goals.
What is the main purpose of this program?
The program supports institutions and organizations that will maintain or establish Integrated Translational Science Centers aligned with the NCI National Clinical Trials Network (NCTN). The aim is to strengthen how NCTN Network Groups embed translational science into the design and execution of clinical trials so trials generate biologic and mechanistic insights in addition to testing treatments.
What is an Integrated Translational Science Center expected to do?
These centers are expected to function as a hub that provides leadership, specialized expertise, and operational support so Network Group trials consistently include well-planned translational components and workflows.
Is the support intended for one specific clinical trial or across multiple trials?
The expectation is that the center provides scientific direction and coordination for translational efforts across Network Group trials, not one-off support for a single study.
What kinds of translational activities are specifically mentioned?
Examples mentioned include biospecimen collection, biomarker development, correlative science, and other research activities that connect patient outcomes with underlying biology.
How does this program influence clinical trial design and execution?
The centers are intended to help investigators identify translational questions that can realistically be answered within clinical trial settings, ensure appropriate infrastructure and workflows are in place, and improve the overall quality and feasibility of translational endpoints.
Does the opportunity include support for pilot projects?
Yes. The FOA explicitly includes support for pilot projects that collect preliminary data.
What is the role of pilot projects in this program?
Pilot activities allow Network Groups to test ideas, optimize methods, and generate early evidence that can justify and reduce risk for larger and more definitive translational components in later clinical trials.
Who is eligible to apply?
Eligible applicants include U.S.-based organizations such as state governments; public and state-controlled institutions of higher education; private institutions of higher education; non-profit organizations (with or without 501(c)(3) status, provided they are not institutions of higher education); and for-profit organizations other than small businesses.
Are any special categories of institutions highlighted as eligible?
Yes. The FOA highlights categories that commonly appear in federal funding, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and U.S. territories or possessions.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply.
Can a U.S. organization include a non-U.S. component in its application?
No. Non-U.S. components of U.S. organizations are not eligible to apply as components.
Are any international collaborations allowed at all?
Yes. "Foreign components" (as defined under the NIH Grants Policy Statement) are allowed. This means certain discrete collaborations or activities involving foreign entities may be permissible when they meet NIH definitions and policy requirements, even though the applicant organization itself must be eligible and U.S.-based.
Which agency and institute are associated with this opportunity?
This is a National Institutes of Health (NIH) funding opportunity associated with the National Cancer Institute (NCI).
How does this opportunity relate to the NCI National Clinical Trials Network (NCTN)?
The centers supported under this FOA are intended to be aligned with the NCTN and designed to strengthen translational science capabilities within NCTN Network Groups and their clinical trials.
What broad federal activity categories does this opportunity fall under?
The opportunity is described as falling under NIH education and health activity categories.
What CFDA numbers are associated with this funding opportunity?
The CFDA numbers listed are 93.394 and 93.395.
When was the funding opportunity originally posted?
The original posting date is October 20, 2017.
What was the original application closing date?
The original application closing date is January 19, 2018.
What is the listed award ceiling?
The listed award ceiling is $850,000.
Does the excerpt specify whether the $850,000 ceiling is for direct costs or total costs?
No. The excerpt notes that the ceiling signals the intended scale for a single award's annual direct costs or total costs depending on the FOA's specific budget instructions, and that applicants would need to confirm in the full announcement.
How many awards are expected to be made?
The excerpt does not provide a definitive number of expected awards, but it suggests a targeted set of awards intended to align with NCTN Network Groups and their translational needs.
How should an organization think about the overall nature of the funding?
It is best understood as capacity-building and integration funding: supporting organizational leadership, shared expertise, and pilot translational research so translational science becomes a consistent, high-quality element of NCTN clinical trials rather than an add-on that varies across studies.
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