Opportunity Information: Apply for RFA HG 26 008
The funding opportunity titled "Single Source: Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network - Coordinating Center (U01 Clinical Trial Required)" is a National Institutes of Health (NIH) Notice of Funding Opportunity (NOFO) issued by the National Human Genome Research Institute (NHGRI). It is specifically designed as a single-source cooperative agreement solicitation, meaning it is not an open competition among many applicants. Instead, it invites a particular organization that previously held the eMERGE Coordinating Center award under RFA-HG-19-015 to apply in order to continue coordinating the next phase of the eMERGE Genomic Risk Assessment and Management Network.
The purpose of the award is to support a Coordinating Center that will manage and sustain network-wide activities focused on outcomes research tied to genomically informed risk assessment (GIRA) and related clinical management recommendations. The network is expected to continue follow-up and collect outcome data through April 2030 for a large cohort of roughly 25,000 patients who have received GIRA and accompanying guidance for clinical care. In practical terms, the Coordinating Center role typically includes organizing multi-site collaboration, maintaining consistent processes and timelines, supporting data harmonization across participating sites, facilitating communications and meetings, and ensuring that outcome collection efforts remain aligned with the network's scientific goals and operational requirements.
This NOFO uses the U01 mechanism, which is a cooperative agreement. That structure generally indicates substantial NIH involvement in the project, with the awardee and NIH program staff working collaboratively on scientific and operational decisions. The listing also notes "Clinical Trial Required," signaling that the work is expected to include clinical trial elements as defined by NIH policy, such as prospective assignment of human participants to an intervention (which, in genomics implementation contexts, can include return of results and downstream care pathways) and the evaluation of health-related outcomes.
NHGRI states its intent to make a single award, and it identifies Vanderbilt University Medical Center as the intended recipient for this continuation effort. Although the application will still go through NIH peer review using standard NIH processes, the NOFO makes clear that it is a single-source action and that only meritorious applications will be considered. Eligibility is correspondingly narrow and tied to the prior award relationship, with applicants directed to Section III of the NOFO for the formal eligibility language.
Administratively, the opportunity is classified as discretionary funding and falls under the health activity category, with CFDA (Assistance Listing) number 93.172. The funding opportunity number is RFA HG 26 008. The expected number of awards is one, with an award ceiling of $687,000. The NOFO was created on 2026-01-30, and the original application closing date is 2026-03-06. Overall, the opportunity is best understood as a continuation and extension of the existing eMERGE coordinating infrastructure to ensure long-term, consistent follow-up and outcomes data collection for patients who have received genomics-informed risk assessment and management within the eMERGE network through 2030.Apply for RFA HG 26 008
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Single Source: Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network - Coordinating Center (U01 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
- This funding opportunity was created on 2026-01-30.
- Applicants must submit their applications by 2026-03-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $687,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others.
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